fig2

Figure 2. Exocytosis of the two organelles (B) and their released material spread in the extracellular space (A). Analogous to the exosomes in Figure 1, these images of an endo-lysosome and an autophagosome illustrate exocytoses with release to the extracellular space. However, the two exocytosis forms differ concerning exosomes in Figure 1 and from one another. The endo-lysosome B image is delimited by a membrane combination induced by the fusion of a lysosome (black, the same color as the plasma membrane) with an endocytic cisterna (sky blue). The other B comes from a mature autophagosome with a membrane drawn in a candy color. The discharged cargoes (A) of endo-lysosome includes various types of enzyme molecules with degraded organelles, structures, and very few vesicles. The A image of the autophagosome shows some preservation of various structures, including cytoplasmic organelles (mitochondrion, endoplasmic reticulum, Golgi complex) and a significant number of vesicles, variable in size, color, and membrane, likely originated from the autophagy of various cytoplasmic structures.