fig3
Figure 3. TNTs facilitate the transfer of NDs-causing protein aggregates. A: Unhealthy cells containing protein aggregates can form TNTs with a naïve, healthy cell, eventually spreading aggregates such as PrPSc (Prion’s disease), Tau and Amyloid-β (AD), α-Syn fibrils (PD), and mHtt (HD). B: Such transfers can happen between the same type of cells via homotypic TNTs (left panels), or between different cell types via heterotypic TNTs (right panels).
