fig5

Figure 5. The levels of five synaptic proteins, NRGN, GAP43, PSD95, Syntaxin-1, and GluR2, were measured in three independent cohorts. (A-I) NDEVs-associated NRGN, GAP43, PSD95, Syntaxin-1, and GluR2 were measured in the NIA cohort (20 AD and 19 controls; NRGN: P = 0.025, GAP43: P < 0.001, PSD95: P = 002, Syntaxin-1: P = 0.011, and GluR2: P < 0.001). (B-J) The same proteins were measured in the combined BioIVT/PMED cohort (40 AD and 19 controls total), NRGN: P = 0.087, GAP43: P = 0.063, PSD95: P = 0.2, Syntaxin-1: P = 0.03 and GluR2: P < 0.001). (K) ROC analysis was conducted for all three cohorts combined. Each line corresponds to a different NDEV biomarker; higher values indicate AD/MCI, and lower values indicate CN Control status.