fig1

Figure 1. EV biogenesis and cellular processing. EV endocytosis, intracellular trafficking, and cargo release may result in phenotypic changes in recipient cells. It remains to be established if, within MVBs, there is a mixed presence of newly-formed ILVs and internalized EVs (mixture hypothesis) or that MVBs contain either ILVs or EVs (segregation hypothesis). This image was created with BioRender (https://biorender.com/).