- Prof. Long Zhang
Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China.
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Special Issue Introduction
Exosomes are spherical structures with a 30-130 nm diameter, containing bioactive substances such as proteins, lipids, mRNA, miRNA, small non-coding RNA, and genomic DNA of donor cells. These encapsulated biological macromolecules can play a series of roles in target cells and are important mediums of indirect cell communication. A key function of exosomes is to transport their cargo from donor cells to recipient cells, allowing for genetic and phenotypic modification of the recipient cells. Since circulating exosomes released from tumor cells appear to be cancer type-specific, exosomes can be used as a novel, non-invasive, highly reliable, and real-time specific biomarkers for cancer diagnosis and prognosis, and changes in exosome characteristics are closely associated with initiation, progression, treatment resistance, and recurrence of various cancers. As for tumor-derived exosomes, they can change the tumor microenvironment, weaken anti-tumor immunity and promote the immune escape of tumors. Therefore, targeting tumor-derived exosomes has become a new strategy for cancer treatment. In addition, the endogenous nature of exosomes enables them to be characterized by good biocompatibility and low immunogenicity. Their small size allows them to cross physiological and pathological barriers such as the cytoplasmic membrane and the blood/brain barrier to deliver the substances they carry to the underlying tissues, making them ideal for delivering therapeutic molecules. The potential of exosomes has been gradually revealed in recent years, and its potential applications in cancer can be classified into three categories: as tumor-specific biomarkers for cancer diagnosis and prognosis; cancer therapy by targeting tumor-derived exosomes; as a drug carrier, used for cancer treatment, etc.
This Special Issue aims to promote investigations focusing on the molecular and cellular mechanisms of exosomes in tumor therapy, their role as specific markers in tumor diagnosis, and their applications as drug carriers in tumor-targeted therapy. We welcome submissions of Original Research and Review articles focusing on the following aspects:
● The role of exosomes in tumorigenesis, progression, tumor immunity, and therapeutic resistance
● The investigation of exosomes as biomarkers in tumor diagnosis
● The application of exosomes carrying target genes and drug molecules in the field of cancer therapy
Exosomes, cancer therapy, biomarkers, diagnosis, delivery, drug carriers
Submission Deadline31 Jan 2022