Guest Editor(s)
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- Lynn Pulliam
Professor, Laboratory Medicine and Medicine, University of California San Francisco, San Francisco, CA, USA.
Website | E-mail
Special Issue Introduction
Neuroinflammation is a product and consequence of many different insults. It can be the result of head injury, infections, and aging. While in some cases, the etiologic agent may be transient, the neuroinflammation may persist. With the discovery of extracellular vesicles (EV) produced by all cells, including neural cells, and are essential in normal cell-to-cell communication, studies show they can also carry deleterious cargo. This selective baggage includes RNA, abundant miRNA, DNA, and proteins. Depending on the insult, cells may use EVs as waste disposal in a protective manner or sentinels for cellular injury. In addition, EVs can modulate the fragile neuro environment by influencing the immune response by releasing EVs containing selected inflammatory or protective cargos or stimulating neurogenesis. EVs are capable of traveling across the blood-brain barrier. They can be isolated from blood and used as liquid biopsies for neuropathologies dependent on invasive techniques to diagnose. Alternatively, stem cell EVs with low immunogenicity may be used as a therapy to stimulate neurogenesis and attenuate neuroinflammation upstream by engineering EVs with anti-inflammatory miRNAs.
This special issue will explore how neural EVs can be used as biomarkers and potential therapies for neuroinflammation and will include original research articles and reviews associated with neuroinflammation and EVs in the following topics:
● TBI, stroke;
● Neural infections;
● Alzheimer’s disease;
● Therapy.
Submission Deadline
31 Mar 2022
Extracellular Vesicles and Circulating Nucleic Acids
